Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316270 | 0.91 | LMNA (0.53) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL9255947 | 0.85 | NPC1 (0.47) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL11037946 | 0.84 | LMNA (0.53) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL9250126 | 0.83 | NPC1 (0.44) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL9316272 | 0.82 | LMNA (0.51) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL9254905 | 0.82 | NPC1 (0.46) | LMNANPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2773681 | 0.80 | MAPT (0.52) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL9254186 | 0.79 | GSK3B (0.50) | MAPTKMT2AMEN1TDP1MAPK1 | |
| SCHEMBL2773685 | 0.78 | LMNA (0.50) | POLBLMNANPC1RAB9AMAPT | |
| SCHEMBL10570188 | 0.78 | TSHR (0.52) | POLBLMNANPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0205857-A2 | 5,6-Epoxy-7-oxabicycloheptane substituted prostaglandin analogs | E.R. Squibb & Sons, Inc. (US) | 1986-12-30 | — | — | EP | disclosed |