Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10875629 | 0.82 | MAPT (0.45) | NPC1RAB9ALMNAMEN1KMT2A | |
| SCHEMBL10921382 | 0.80 | PTPN1 (0.39) | LTA4HNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL10881031 | 0.76 | TSHR (0.55) | LMNASMN1; SMN2ALDH1A1MAPTTSHR | |
| SCHEMBL10949689 | 0.74 | MAOB (0.34) | LTA4HNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL10917798 | 0.74 | SRD5A2 (0.49) | NPC1RAB9ALMNASMN1; SMN2TP53 | |
| SCHEMBL10949682 | 0.73 | ESR2 (0.35) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL10878126 | 0.72 | POLB (0.30) | — | |
| SCHEMBL10655743 | 0.67 | HPGD (0.52) | LMNAKMT2AALDH1A1MAPTHPGD | |
| SCHEMBL238259 | 0.66 | LTA4H (0.73) | LTA4HNPC1RAB9ALMNASMN1; SMN2 | |
| SCHEMBL8572071 | 0.66 | LTA4H (0.73) | LTA4HNPC1RAB9ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064707-B1 | 4-(4-PHENYL-1-PIPERIDINYL)METHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0065165-B1 | 5-OXYMETHYL-4-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-06-18 | — | — | EP | disclosed |
| EP-0064704-B1 | 4-AMINOMETHYL-5-ACYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1986-04-16 | — | — | EP | disclosed |
| US-4526981-A | [1,2-Dihydro-4(5)-acyl-2-oxo-2H-imidazol-4(5)-yl] methyl nitrates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1985-07-02 | — | — | US | disclosed |
| US-4381393-A | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1983-04-26 | — | — | US | disclosed |
| EP-0065165-A1 | 5-Oxymethyl-4-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-24 | — | — | EP | disclosed |
| EP-0064704-A1 | 4-Aminomethyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| EP-0064707-A1 | 4-(4-Phenyl-1-piperidinyl)methyl-5-acyl-1,3-dihydro-2H-imidazol-2-ones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4329471-A | CARDIOTONICS, HYPOTENSIVE AGENTS, AND ANTITHROMBOTIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1982-05-11 | — | — | US | disclosed |