Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | POLB | P06746 | 2/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 5/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10876746 | 0.99 | NPC1 (0.63) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL10877054 | 0.86 | NPC1 (0.61) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL11040780 | 0.85 | NPC1 (0.60) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL10881018 | 0.84 | SMN1; SMN2 (0.58) | NPC1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10878171 | 0.84 | NPC1 (0.67) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL10880785 | 0.83 | RAB9A (0.64) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL22192215 | 0.82 | NPC1 (0.86) | NPC1MAPTRAB9ASMN1; SMN2POLB | |
| SCHEMBL10878024 | 0.82 | MAPT (0.51) | NPC1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10878734 | 0.81 | SMN1; SMN2 (0.54) | NPC1MAPTRAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL10879495 | 0.78 | CYP2D6 (0.74) | NPC1MAPTRAB9ASMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100051-B1 | NEW DERIVATIVES OF 1-ALKYLAMINE-(4(P-ALKYLOXY-BENZAMIDE)PHENOXY)-2-PROPANOL, HAVING BETA-SYMPATHOLYTIC ACTIVITY, THEIR SALTS, AND PRODUCTION PROCESSES THEREOF | A. Menarini S.a.S. (IT) | 1986-04-09 | — | — | EP | disclosed |