SCHEMBL10880846

SCHEMBL10880846

O=C1NC(=O)N([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C(O)C1F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDA P32320 9/20 0.47
SLC28A1 O00337 1/20 0.46
SLC28A2 O43868 1/20 0.46
SLC29A1 Q99808 1/20 0.46
SLC28A3 Q9HAS3 1/20 0.46
PYGM P11217 2/20 0.43
GMNN O75496 1/20 0.41
ALDH1A1 P00352 1/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
NFKB1 P19838 1/20 0.41
DNMT1 P26358 1/20 0.41
THPO P40225 1/20 0.41
MTOR P42345 1/20 0.41
HTT P42858 1/20 0.41
RAB9A P51151 1/20 0.41
BLM P54132 1/20 0.41
HBB P68871 1/20 0.41
PMP22 Q01453 1/20 0.41
MAPT P10636 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10880866 1.00 CDA (0.47) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL14853649 0.85 CDA (0.49) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL14930955 0.85 CDA (0.49) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL14929091 0.85 CDA (0.49) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL14930961 0.83 CDA (0.50) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL14929151 0.83 CDA (0.50) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL12157279 0.83 CDA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL12174053 0.83 CDA (0.42) CDASLC28A1SLC28A2SLC29A1SLC28A3
SCHEMBL11406434 0.81 UMPS (0.50)
SCHEMBL11406428 0.81 UMPS (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-55028926-A None JP disclosed
JP-60004198-A None JP disclosed
EP-0111299-B1 FLUORINE-CONTAINING URIDINE DERIVATIVE AND PREPARATION AND USE THEREOF Daikin Kogyo Co., Ltd. (JP) 1986-04-02 EP disclosed
US-4542209-A Fluorine-containing uridine derivative and preparation and use thereof DAIKIN KOGYO CO., LTD. (JP) 1985-09-17 US disclosed
JP-S604198-A 5-FLUORODEOXYURIDINE DERIVATIVE AND ITS PREPARATION OZAKI SHOICHIRO 1985-01-10 JP disclosed
EP-0111299-A1 Fluorine-containing uridine derivative and preparation and use thereof Daikin Kogyo Co., Ltd. (JP) 1984-06-20 EP disclosed
JP-S5528926-A PREPARATION OF 5-FLUORO-URIDINE MITSUI TOATSU CHEM INC 1980-02-29 JP disclosed