SCHEMBL10880992

SCHEMBL10880992

CC1(C)C(C=C(F)F)C1C(=O)OC1Cc2cccc(-c3ccccc3)c2C1

nearest known ligand 0.39

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.36
LMNA P02545 1/20 0.36
ADRA2A P08913 1/20 0.36
CNR1 P21554 1/20 0.36
ATM Q13315 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
FABP7 O15540 2/20 0.35
FABP5 Q01469 2/20 0.35
FABP3 P05413 1/20 0.35
HTR1A P08908 2/20 0.34
HTR7 P34969 2/20 0.34
ALDH1A1 P00352 1/20 0.34
CYP1A2 P05177 1/20 0.33
TSHR P16473 1/20 0.33
CYP2C19 P33261 1/20 0.33
SCN1A P35498 1/20 0.33
SCN2A Q99250 1/20 0.33
SCN3A Q9NY46 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10881004 1.00 TDP1 (0.36) TDP1LMNAADRA2ACNR1ATM
SCHEMBL10880995 1.00 TDP1 (0.36) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11153443 0.91 LMNA (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11031944 0.91 LMNA (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11031941 0.91 LMNA (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11226714 0.91 LMNA (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11150126 0.90 FABP7 (0.35) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11249269 0.88 TDP1 (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11249272 0.88 TDP1 (0.43) TDP1LMNAADRA2ACNR1ATM
SCHEMBL11220701 0.88 TDP1 (0.43) TDP1LMNAADRA2ACNR1ATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0118873-B1 ACARICIDAL DIFLUOROETHENYLCYCLOPROPANECARBOXYLATES FMC Corporation (US) 1986-06-18 EP disclosed
US-4552892-A Acaricidal difluoroethenylcyclopropanecarboxylates FMC CORPORATION (US) 1985-11-12 US disclosed
EP-0118873-A1 Acaricidal difluoroethenylcyclopropanecarboxylates FMC Corporation (US) 1984-09-19 EP disclosed