Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 11/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.58 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.54 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10881661 | 0.90 | NPC1 (0.67) | NPC1ALDH1A1CYP1A2KDM4ERAB9A | |
| SCHEMBL14063125 | 0.89 | RAB9A (0.63) | NPC1ALDH1A1CYP1A2KDM4ERAB9A | |
| SCHEMBL10735257 | 0.87 | NPC1 (0.78) | NPC1ALDH1A1KDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL14063123 | 0.83 | NPC1 (0.56) | NPC1ALDH1A1CYP1A2KDM4ERAB9A | |
| SCHEMBL5144110 | 0.82 | KMT2A (0.59) | NPC1ALDH1A1CYP1A2RAB9ASMN1; SMN2 | |
| SCHEMBL9537966 | 0.82 | KMT2A (0.59) | NPC1ALDH1A1CYP1A2RAB9ASMN1; SMN2 | |
| SCHEMBL410250 | 0.81 | PKM (0.76) | ALDH1A1CYP1A2SMN1; SMN2TP53LMNA | |
| SCHEMBL6099389 | 0.81 | PKM (0.76) | ALDH1A1CYP1A2SMN1; SMN2TP53LMNA | |
| SCHEMBL5994567 | 0.81 | PKM (0.76) | ALDH1A1CYP1A2SMN1; SMN2TP53LMNA | |
| SCHEMBL6799157 | 0.81 | RAB9A (1.00) | NPC1ALDH1A1CYP1A2KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100051-B1 | NEW DERIVATIVES OF 1-ALKYLAMINE-(4(P-ALKYLOXY-BENZAMIDE)PHENOXY)-2-PROPANOL, HAVING BETA-SYMPATHOLYTIC ACTIVITY, THEIR SALTS, AND PRODUCTION PROCESSES THEREOF | A. Menarini S.a.S. (IT) | 1986-04-09 | — | — | EP | disclosed |
| US-4503075-A | ADRENERGIC BLOCKING AGENTS | A. MENARINI S.A.S. (IT) | 1985-03-05 | — | — | US | disclosed |