SCHEMBL10885131

SCHEMBL10885131

O=C=Nc1ccc(Cl)cc1CCl

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 3/20 0.37
TDP1 Q9NUW8 2/20 0.37
GABRA1 P14867 1/20 0.37
GABRB2 P47870 1/20 0.37
CYP3A4 P08684 7/20 0.37
HPGD P15428 3/20 0.37
ALDH1A1 P00352 2/20 0.37
HIF1A Q16665 4/20 0.35
IDO1 P14902 2/20 0.35
MAPT P10636 2/20 0.35
MEN1 O00255 2/20 0.35
ALOX15 P16050 2/20 0.35
KMT2A Q03164 2/20 0.35
SLC22A1 O15245 1/20 0.35
USP2 O75604 1/20 0.35
LMNA P02545 1/20 0.35
HSP90AA1 P07900 1/20 0.35
HSPD1 P10809 1/20 0.35
HSPA5 P11021 1/20 0.35
ALOX12 P18054 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8093673 0.87 GABRA1 (0.48) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL11464398 0.85 TDP1 (0.35) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL27609924 0.85 CYP2A6 (0.38) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL10885710 0.85 MAPK1 (0.37) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL7704447 0.81 CYP3A4 (0.33) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL11763846 0.81 CYP3A4 (0.52) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL9551375 0.81 CYP3A4 (0.39) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL30111366 0.79 TDP1 (0.42) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL10316536 0.79 TDP1 (0.42) MAPK1TDP1GABRA1GABRB2CYP3A4
SCHEMBL10883870 0.79 CYP3A4 (0.40) MAPK1TDP1GABRA1GABRB2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0009787-B2 PROCESS FOR THE MONOHALOGENATION OF ALKYLBENZENES IN ALPHA POSITION BAYER AG (DE) 1986-07-09 EP disclosed
US-4331821-A ULTRAVIOLET RADIATION OF A VAPORIZED ALKYLBENZEN AND HALOGEN GAS MIXTURE BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed
EP-0009787-A2 Process for the monohalogenation of alkylbenzenes in alpha position BAYER AG (DE) 1980-04-16 EP disclosed