Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.44 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | MEP1A | Q16819 | 1/20 | 0.41 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10889808 | 0.95 | ALDH1A1 (0.48) | ALDH1A1L3MBTL1NPC1MAPTPOLB | |
| SCHEMBL10890079 | 0.91 | ALDH1A1 (0.52) | ALDH1A1MAPTPOLBLIMK1LIMK2 | |
| SCHEMBL10885751 | 0.85 | ALDH1A1 (0.49) | ALDH1A1L3MBTL1NPC1MAPTTAS2R14 | |
| SCHEMBL11751675 | 0.85 | MAPT (0.62) | ALDH1A1L3MBTL1MAPTPPARGTMEM97 | |
| SCHEMBL10883703 | 0.82 | ALDH1A1 (0.44) | ALDH1A1L3MBTL1NPC1MAPTPOLB | |
| SCHEMBL10886405 | 0.80 | ALDH1A1 (0.39) | ALDH1A1L3MBTL1NPC1MAPTPOLB | |
| Hydrochloric Acid SCHEMBL6423777 | 0.79 | POLB (0.52) | ALDH1A1POLBLIMK1LIMK2MEN1 | |
| SCHEMBL10886738 | 0.79 | ACHE (0.56) | ALDH1A1L3MBTL1NPC1MAPTPOLB | |
| SCHEMBL10882625 | 0.79 | CA12 (0.57) | ALDH1A1L3MBTL1NPC1MAPTPOLB | |
| SCHEMBL7486280 | 0.77 | HPGD (0.47) | ALDH1A1POLBLIMK1LIMK2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0086450-B1 | SUBSTITUTED PHENYLPYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, MEDICINES BASED ON THESE COMPOUNDS AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1986-05-28 | — | — | EP | disclosed |
| EP-0086450-A2 | Substituted phenylpyrazole derivatives, process for their preparation, medicines based on these compounds and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-08-24 | — | — | EP | disclosed |