Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10890451 | 0.85 | MCL1 (0.58) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10889950 | 0.83 | MCL1 (0.60) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10998515 | 0.81 | PDGFRB (0.47) | ALDH1A1KDM4EHPGDPDGFRBPDGFRA | |
| SCHEMBL10887196 | 0.80 | MCL1 (0.56) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10889210 | 0.79 | HPGD (0.53) | ALDH1A1KDM4EHPGDPDGFRBPDGFRA | |
| SCHEMBL10997804 | 0.78 | PDGFRB (0.44) | ALDH1A1KDM4EPDGFRBPDGFRAMAPT | |
| SCHEMBL10886834 | 0.77 | MCL1 (0.66) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10890189 | 0.75 | MCL1 (0.68) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10887360 | 0.74 | KDM4E (0.63) | MCL1ALDH1A1KDM4EHPGDPIK3CD | |
| SCHEMBL10886965 | 0.72 | KDM4E (0.64) | MCL1ALDH1A1KDM4EHPGDPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599423-A | Preparation of 5-(hydroxy- and/or aminophenyl-6-lower-alkyl)-2(1H)-pyridinones | STERLING DRUG INC. (US) | 1986-07-08 | — | — | US | disclosed |
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |
| US-4465686-A | 5-(Hydroxy- and/or amino-phenyl)-6-(lower-alkyl)-2-(1H)-pyridinones, their cardiotonic use and preparation | STERLING DRUG INC. (US) | 1984-08-14 | — | — | US | disclosed |
| EP-0061774-A2 | 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1982-10-06 | — | — | EP | disclosed |