Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | GRK6 | P43250 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10998585 | 0.85 | MAPT (0.41) | ALDH1A1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL11000584 | 0.85 | PARP1 (0.49) | PDGFRBMAPTKDM4EGAAMEN1 | |
| SCHEMBL10998515 | 0.83 | PDGFRB (0.47) | PDGFRBPDGFRAALDH1A1MAPTGRK6 | |
| SCHEMBL10996706 | 0.82 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4ETDP1L3MBTL1 | |
| SCHEMBL10992833 | 0.80 | KDM4E (0.43) | PDGFRBPDGFRAALDH1A1MAPTGRK6 | |
| SCHEMBL10890717 | 0.78 | MCL1 (0.51) | PDGFRBPDGFRAALDH1A1MAPTGRK6 | |
| SCHEMBL11000486 | 0.77 | CASP1 (0.48) | ALDH1A1MAPTPOLBL3MBTL1LMNA | |
| SCHEMBL10997254 | 0.76 | CASP1 (0.47) | ALDH1A1KDM4EGAASMN1; SMN2 | |
| SCHEMBL25295556 | 0.76 | ALDH1A1 (0.52) | ALDH1A1MAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL10992087 | 0.74 | CDC7 (0.50) | ALDH1A1MAPTPOLBTDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4559352-A | 1,2-Dihydro-2-oxo-5-(hydroxy-and/or amino-phenyl)-nicotinonitriles and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-12-17 | — | — | US | disclosed |
| US-4515797-A | 3-Amino-5-(hydroxy- and/or aminophenyl)-6-(lower-alkyl)-2(1H)-pyridinones and cardiotonic use thereof | STERLING DRUG INC. (US) | 1985-05-07 | — | — | US | disclosed |
| EP-0061774-A2 | 3-Amino-5-(substituted)-2 (1H) pyridinones and 3-cyano compounds useful as cardiotonics and preparation thereof | STERLING DRUG INC. (US) | 1982-10-06 | — | — | EP | disclosed |