SCHEMBL1089252

SCHEMBL1089252

CC(C(=O)O)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.50

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
NPC1 O15118 1/20 0.50
SLC22A2 O15244 1/20 0.48
SLC47A1 Q96FL8 1/20 0.48
MAPT P10636 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
EPHX2 P34913 5/20 0.43
NPSR1 Q6W5P4 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
EPHX1 P07099 1/20 0.41
DPP4 P27487 1/20 0.41
P2RX7 Q99572 1/20 0.39
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.39
GAA P10253 1/20 0.39
CYP2C19 P33261 1/20 0.39
ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15149727 1.00 ALDH1A1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL17628726 0.91 ALDH1A1 (0.39) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL17628724 0.91 ALDH1A1 (0.39) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL26217989 0.87 ALDH1A1 (0.43) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL6858920 0.82 ALDH1A1 (0.40) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL8073575 0.82 ALDH1A1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL4138799 0.82 NPC1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL7706555 0.81 ALDH1A1 (0.39) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL13148519 0.81 DPP4 (0.48) ALDH1A1NPC1DPP4CYP3A4
SCHEMBL1088842 0.81 TSHR (0.42) ALDH1A1NPC1SLC22A2SLC47A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117447466-A Oxazole compound and preparation method and application thereof 中国科学院上海药物研究所 2024-01-26 CN disclosed
CN-110167924-A For treating the composition and method of the cancer of EZH2 mediation 西奈山伊坎医学院 2019-08-23 CN disclosed
CN-106414413-A Sulfonamide derivatives and pharmaceutical use thereof EA制药株式会社 2017-02-15 CN disclosed
US-8535872-B2 Thermally cured underlayer for lithographic application FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. (US) 2013-09-17 US disclosed
WO-2012163456-A1 NOVEL P2X7R ANTAGONISTS AND THEIR USE AFFECTIS PHARMACEUTICALS AG (DE) 2012-12-06 WO disclosed
US-20120178871-A1 THERMALLY CURED UNDERLAYER FOR LITHOGRAPHIC APPLICATION DE BINOD B (US) 2012-07-12 US disclosed
US-8153346-B2 Hydroxyl containing polymer, amino crosslinking agent and thermal acid generator; undercoating for multilayer lithography material FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. (US) 2012-04-10 US disclosed
JP-2011057618-A PROCESS FOR PRODUCING OPTICALLY ACTIVE ADAMANTYLPROPIONIC ACID, CRYSTAL MATERIAL, DIASTEREOMER SALT AND PROCESS FOR PRODUCING THE SAME TOKAI UNIV 2011-03-24 JP disclosed
US-7727705-B2 High etch resistant underlayer compositions for multilayer lithographic processes FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. (US) 2010-06-01 US disclosed
WO-2008103776-A2 THERMALLY CURED UNDERLAYER FOR LITHOGRAPHIC APPLICATION FUJIFILM ELECTRONIC MATERIALS U.S.A., INC. (US) 2008-08-28 WO disclosed
US-20080206676-A1 THERMALLY CURED UNDERLAYER FOR LITHOGRAPHIC APPLICATION FUJIFILM ELECTRONIC MATERIALS, U.S.A, INC 2008-08-28 US disclosed
US-20080206667-A1 HIGH ETCH RESISTANT UNDERLAYER COMPOSITIONS FOR MULTILAYER LITHOGRAPHIC PROCESSES FUJIFILM ELECTRONIC MATERIALS, U.S.A., INC. 2008-08-28 US disclosed
EP-0661271-B1 AZEPINE DERIVATIVES, PRODUCTION THEREOF, AND USE THEREOF AS SIGMA-RECEPTOR LIGANDS ASAHI CHEMICAL IND (JP) 2000-04-26 EP disclosed
US-5658923-A USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1997-08-19 US disclosed
EP-0661271-A1 AZEPINE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1995-07-05 EP disclosed