SCHEMBL8073575

SCHEMBL8073575

CC(=O)C(C)C12CC3CC(CC(C3)C1)C2

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.50
NPC1 O15118 1/20 0.50
SLC22A2 O15244 1/20 0.48
SLC47A1 Q96FL8 1/20 0.48
MAPT P10636 1/20 0.46
EPHX2 P34913 6/20 0.43
CA2 P00918 1/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
EPHX1 P07099 1/20 0.41
DPP4 P27487 1/20 0.41
P2RX7 Q99572 1/20 0.39
POLB P06746 1/20 0.39
CYP3A4 P08684 1/20 0.39
GAA P10253 1/20 0.39
CYP2C19 P33261 1/20 0.39
TSHR P16473 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1089252 0.82 ALDH1A1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL4138799 0.82 NPC1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL15149727 0.82 ALDH1A1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL29201779 0.77 ALDH1A1 (0.51) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL10069253 0.76 DPP4 (0.54) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL14673444 0.75 ALDH1A1 (0.44) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL18424574 0.72 ALDH1A1 (0.50) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL14947775 0.72 ALDH1A1 (0.46) ALDH1A1NPC1SLC22A2SLC47A1EPHX2
SCHEMBL17628726 0.71 ALDH1A1 (0.39) ALDH1A1NPC1SLC22A2SLC47A1MAPT
SCHEMBL17628724 0.71 ALDH1A1 (0.39) ALDH1A1NPC1SLC22A2SLC47A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641208-B1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO INC (US) 2000-08-02 EP claimed
EP-0778284-A2 New 7-beta-substituted-4-aza-5alpha-androstan-3-ones as 5alpha-reductase inhibitors MERCK & CO. INC. (US) 1997-06-11 EP claimed
EP-0641208-A4 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS. MERCK & CO INC (US) 1995-08-30 EP claimed
EP-0641208-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO. INC. (US) 1995-03-08 EP claimed
WO-1993023420-A1 NEW 7β-SUBSTITUTED-4-AZA-5α-ANDROSTAN-3-ONES AS 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
WO-1993023039-A1 SUBSTITUTED 4-AZA-5A-ANDROSTAN-ONES AS 5A-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
WO-1993023048-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
EP-0641208-B1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO INC (US) 2000-08-02 EP disclosed
WO-1993023048-A1 4-AZASTEROID 5-ALPHA-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO disclosed