Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10896122 | 0.83 | TSHR (0.45) | KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL5141716 | 0.80 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL14916471 | 0.79 | ALDH1A1 (0.54) | KMT2AMEN1ALDH1A1GAANPC1 | |
| SCHEMBL10898658 | 0.78 | KDM4E (0.39) | KMT2AMEN1ALDH1A1GAAPOLB | |
| SCHEMBL14113763 | 0.74 | ALDH1A1 (0.38) | KMT2AMEN1ALDH1A1GAATDP1 | |
| SCHEMBL7759384 | 0.73 | ALDH1A1 (0.42) | KMT2AMEN1ALDH1A1GAATDP1 | |
| SCHEMBL6641681 | 0.71 | KMT2A (0.44) | KMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL7384066 | 0.71 | KMT2A (0.51) | KMT2AMEN1TDP1NPC1POLB | |
| SCHEMBL3136218 | 0.70 | P2RX7 (0.46) | KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL20921329 | 0.69 | ATM (0.42) | KMT2AMEN1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0117675-B1 | BENZOFURAN AND BENZOTHIOPHENE-CARBOXYLIC-ACID DERIVATIVES | BEECHAM GROUP PLC (GB) | 1986-07-23 | — | — | EP | disclosed |
| US-4548948-A | Anti-inflammatory and analgesic benzothiophene and benzafuran derivatives, compositions, and method of use therefor | BEECHAM GROUP P.L.C. (GB) | 1985-10-22 | — | — | US | disclosed |
| EP-0117675-A1 | Benzofuran and benzothiophene-carboxylic-acid derivatives | BEECHAM GROUP PLC (GB) | 1984-09-05 | — | — | EP | disclosed |