Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.54 |
| ▸ | ADRB2 known ✓ | P07550 | 1/20 | 0.54 |
| ▸ | FYN | P06241 | 2/20 | 0.68 |
| ▸ | DRD2 | P14416 | 8/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | CASP1 | P29466 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10885545 | 0.99 | FYN (0.70) | FYNDRD2DRD3LMNAMEN1 | |
| Bromide SCHEMBL7198686 | 0.84 | FYN (0.97) | FYNDRD2DRD3LMNAMEN1 | |
| SCHEMBL7330886 | 0.83 | DRD2 (0.52) | FYNDRD2DRD3LMNADRD4 | |
| SCHEMBL7330888 | 0.83 | DRD2 (0.52) | FYNDRD2DRD3LMNADRD4 | |
| SCHEMBL10606282 | 0.82 | FYN (1.00) | FYNDRD2DRD3LMNAMEN1 | |
| Formic Acid SCHEMBL7797225 | 0.81 | DRD2 (0.49) | FYNDRD2DRD3LMNADRD4 | |
| Formic Acid SCHEMBL7797231 | 0.81 | DRD2 (0.49) | FYNDRD2DRD3LMNADRD4 | |
| SCHEMBL7799143 | 0.80 | DRD3 (0.46) | FYNDRD2DRD3MEN1KMT2A | |
| SCHEMBL7799141 | 0.80 | DRD3 (0.46) | FYNDRD2DRD3MEN1KMT2A | |
| SCHEMBL7799078 | 0.79 | DRD3 (0.56) | FYNDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4588747-A | 1,2,3,4-tetrahydronaphthalene derivatives used as antiglaucoma agents | SYNTHELABO (FR) | 1986-05-13 | — | — | US | disclosed |
| US-4520030-A | 2-DIPROPYLAMINO-5 OR 7-FORMYLAMINO-6-HYDROXY-1,2,3,4-TETRA-HYDRONAPHTHALENE | SYNTHELABO (FR) | 1985-05-28 | — | — | US | disclosed |
| US-4442126-A | PARKINSON*S DISEASE, CARDIOVASCULAR DISORDERS | SYNTHELABO (FR) | 1984-04-10 | — | — | US | disclosed |