Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.52 |
| ▸ | CDC25B | P30305 | 4/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129822 | 0.79 | L3MBTL1 (0.42) | CYP1A2CYP2A6NQO1MAPTKDM4E | |
| SCHEMBL8749346 | 0.78 | CYP1A2 (0.55) | CYP1A2CYP2A6NQO2CYP2D6 | |
| SCHEMBL5782272 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL30011882 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL29370537 | 0.78 | NQO1 (0.57) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL1161428 | 0.78 | CYP2A6 (0.57) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL443362 | 0.78 | NQO1 (0.57) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL1402602 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL21085317 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2A6CDC25BNQO1CASP3 | |
| SCHEMBL21117323 | 0.76 | CYP1A2 (0.52) | CYP1A2CYP2A6CDC25BNQO1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072723-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2018-03-15 | — | — | US | disclosed |
| US-20180072723-A1 | KRAS G12C INHIBITORS | Mirati Therapeutics, Inc. | 2018-03-15 | — | — | US | disclosed |
| CN-104245689-A | Tetrazolinone compounds and its use as pesticides | SUMITOMO CHEMICAL CO | 2014-12-24 | — | — | CN | disclosed |
| EP-0117228-B1 | ANALOGS OF MEVALONOLACTONE AND DERIVATIVES THEREOF, PROCESSES FOR THEIR PRODUCTION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | SANDOZ AG (CH) | 1986-11-05 | — | — | EP | disclosed |
| EP-0117228-A1 | Analogs of mevalonolactone and derivatives thereof, processes for their production, pharmaceutical compositions containing them and their use as pharmaceuticals | SANDOZ AG (CH) | 1984-08-29 | — | — | EP | disclosed |
| WO-1984002903-A1 | MEVALONOLACTONE ANALOGS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | SANDOZ AG (CH) | 1984-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072723-A1 | KRAS G12C INHIBITORS | KRAS, NRAS, HRAS | CYP1A2 4667/4885CYP2A6 3834/4885CDC25B 482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.