SCHEMBL8749346

SCHEMBL8749346

COc1ccc2c(Cl)cccc2c1

nearest known ligand 0.57

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.55
CYP2A6 P11509 2/20 0.55
FLT3 P36888 1/20 0.49
MTNR1A P48039 2/20 0.46
MTNR1B P49286 2/20 0.46
SIRT2 Q8IXJ6 1/20 0.43
SIRT1 Q96EB6 1/20 0.43
SIRT3 Q9NTG7 1/20 0.43
SIRT5 Q9NXA8 1/20 0.43
ACHE P22303 2/20 0.43
RELA Q04206 3/20 0.42
NFE2L2 Q16236 1/20 0.42
NQO2 P16083 1/20 0.42
CYP2D6 P10635 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29235279 0.87 CYP11B1 (0.51) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
SCHEMBL5981298 0.85 CYP1A2 (0.55) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
SCHEMBL29937514 0.81 CYP1A2 (0.41) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
SCHEMBL28782042 0.81 CYP1A2 (0.41) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
Potassium SCHEMBL29937292 0.80 CYP1A2 (0.40) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
SCHEMBL5510892 0.78 CYP1A2 (0.59) CYP1A2CYP2A6FLT3MTNR1AMTNR1B
SCHEMBL29869216 0.78 CYP1A2 (0.57) CYP1A2CYP2A6MTNR1AMTNR1BACHE
SCHEMBL10897643 0.78 CYP1A2 (0.52) CYP1A2CYP2A6NQO2CYP2D6
SCHEMBL443271 0.78 CYP1A2 (0.57) CYP1A2CYP2A6MTNR1AMTNR1BACHE
SCHEMBL1806697 0.77 CYP1A2 (0.55) CYP1A2CYP2A6MTNR1AMTNR1BSIRT2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103420898-B Diaryl piperidines analog derivative and the application as Mutiple Targets anti-depression drug thereof SHANGHAI INSTITUTE OF PHARMACEUTICAL INDUSTRY (CN) 2015-10-28 CN disclosed
CN-103420898-A Diaryl piperidine derivatives and applications thereof as multiple-target-point antidepressants SHANGHAI INST PHARM INDUSTRY 2013-12-04 CN disclosed
WO-2007147775-A1 PROCESS FOR SYNTHESIS OF AROMATIC COMPOUNDS DYSTAR TEXTILFARBEN GMBH & CO DEUTSCHLAND KG (DE) 2007-12-27 WO disclosed
EP-0416038-B1 NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED TROPIX INC (US) 1997-03-26 EP disclosed
EP-0416038-A4 NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED 1992-02-26 EP disclosed
EP-0416038-A1 NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED. TROPIX INC (US) 1991-03-13 EP disclosed
US-4952707-A DECOMPOSITION TO LIGHT EMITTING FLUOROPHORE; ANALYSIS TROPIX, INC. (US) 1990-08-28 US disclosed
WO-1990000164-A1 NOVEL CHEMILUMINESCENT FUSED POLYCYCLIC RING-CONTAINING 1,2-DIOXETANES AND ASSAYS IN WHICH THEY ARE USED TROPIX, INC. (US) 1990-01-11 WO disclosed