Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11069977 | 0.88 | PPARA (0.48) | KAT8PPARAPPARGTDP1IGF1R | |
| SCHEMBL4128840 | 0.88 | ALDH1A1 (0.50) | KAT8ALDH1A1TP53MRGPRX4TDP1 | |
| SCHEMBL11120604 | 0.84 | KAT8 (0.68) | KAT8ALDH1A1PPARAPPARGTDP1 | |
| SCHEMBL11485420 | 0.82 | TSHR (0.47) | KAT8ALDH1A1PPARAPPARGTDP1 | |
| SCHEMBL10898270 | 0.82 | KAT8 (0.70) | KAT8ALDH1A1PPARAPPARGMAPT | |
| SCHEMBL5539478 | 0.81 | IGF1R (0.54) | ALDH1A1TP53MAPTIGF1RALOX15 | |
| SCHEMBL5545868 | 0.79 | IGF1R (0.56) | ALDH1A1TP53MAPTIGF1RALOX15 | |
| SCHEMBL664212 | 0.76 | ALDH1A1 (0.55) | KAT8ALDH1A1TP53MRGPRX4TDP1 | |
| SCHEMBL22032180 | 0.75 | TSHR (0.50) | ALDH1A1TP53PPARAPPARGTDP1 | |
| SCHEMBL15809160 | 0.75 | MRGPRX4 (0.48) | KAT8ALDH1A1TP53PPARAMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0126372-B1 | HALOGENATED PROTEASE INHIBITORS | G.D. Searle & Co. (US) | 1986-07-16 | — | — | EP | disclosed |
| EP-0126372-A1 | Halogenated protease inhibitors | G.D. Searle & Co. (US) | 1984-11-28 | — | — | EP | disclosed |