Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 5/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 5/20 | 0.37 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427167 | 0.90 | STAT3 (0.38) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9427196 | 0.87 | STAT3 (0.52) | KDM4EALDH1A1STAT3HPGDHSD17B10 | |
| SCHEMBL6213034 | 0.82 | KDM4E (0.48) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL9289491 | 0.78 | KDM4E (0.45) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL13326854 | 0.76 | STAT3 (0.48) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL10899211 | 0.75 | KDM4E (0.43) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL8136260 | 0.74 | TOP2A (0.53) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL3290751 | 0.74 | STAT3 (0.41) | KDM4EALDH1A1STAT3HPGDHSD17B10 | |
| SCHEMBL10654436 | 0.73 | KDM4E (0.51) | KDM4EALDH1A1POLBHSP90AA1RXFP1 | |
| SCHEMBL25335713 | 0.72 | LMNA (0.30) | HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4604401-A | QUINOLINE-CARBOXYLIC ACIDS | WARNER-LAMBERT COMPANY (US) | 1986-08-05 | — | — | US | disclosed |
| EP-0169710-A2 | 7-Substituted-6-fluoro-8-substituted-1,4-dihydro-1-methylamino-4-oxo-3-quinolinecarboxylic acids; 7-substituted-6-fluoro-1,4-dihydro-1-methylamino-4-oxo-3-naphthyridine carboxylic acids; derivatives thereof; and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1986-01-29 | — | — | EP | disclosed |