SCHEMBL10899355

SCHEMBL10899355

O=C1CCN(C(=O)C(Cl)Cl)CC1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
LIPE Q05469 1/20 0.37
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
LMNA P02545 1/20 0.35
HSP90AA1 P07900 1/20 0.34
PKM P14618 1/20 0.33
POLB P06746 1/20 0.32
TP53 P04637 1/20 0.31
MDM2 Q00987 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ethylene SCHEMBL10898028 0.96 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2LIPEKMT2AMEN1
Propene SCHEMBL10899374 0.89 ALDH1A1 (0.38) ALDH1A1SMN1; SMN2LIPEKMT2AMEN1
SCHEMBL11401289 0.83 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2LIPEKMT2AMEN1
SCHEMBL10896613 0.80 ALDH1A1 (0.53) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL640493 0.77 LIPE (0.44) ALDH1A1SMN1; SMN2LIPEKMT2AMEN1
SCHEMBL27912479 0.75 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL2142203 0.73 ALDH1A1 (0.46) ALDH1A1SMN1; SMN2KMT2AMEN1TP53
SCHEMBL11195761 0.73 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2KMT2AMEN1LMNA
SCHEMBL10665653 0.73 ALDH1A1 (0.48) ALDH1A1SMN1; SMN2KMT2AMEN1
SCHEMBL1760894 0.73 HSP90AA1 (0.37) ALDH1A1LIPEKMT2ALMNAHSP90AA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4614537-A PLANT SAFENING AGENTS BAYER AKTIENGESELLSCHAFT (DE) 1986-09-30 US disclosed
US-4548639-A N-Acyl-piperidone ketal compounds and their use as antidotes for protecting crop plants from herbicidal damage BAYER AKTIENGESELLSCHAFT (DE) 1985-10-22 US disclosed
EP-0023308-B1 N-ACYL-PIPERIDONE CETALS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTIDOTES IN THE PROTECTION OF CROP PLANTS AGAINST DAMAGE BY HERBICIDES BAYER AG (DE) 1982-12-22 EP disclosed
US-4294967-A HERBICIDE ANTIDOTES BAYER AKTIENGESELLSCHAFT (DE) 1981-10-13 US disclosed
EP-0023308-A1 N-acyl-piperidone cetals, process for their preparation and their use as antidotes in the protection of crop plants against damage by herbicides BAYER AG (DE) 1981-02-04 EP disclosed