Erythromycin

SCHEMBL10899622

CC(=O)O.CCCCCCCCCCCCCCCCCC(=O)O.CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@H](O)[C@]1(C)O

nearest known ligand 0.84

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Erythromycin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	CYP3A4	P08684	9/20	0.84

▸	KCNH2	Q12809	5/20	0.84

▸	ABCB1	P08183	2/20	0.84

▸	TSHR	P16473	2/20	0.84

▸	LMNA	P02545	2/20	0.84

▸	MLNR	O43193	2/20	0.84

▸	TDP1	Q9NUW8	1/20	0.84

▸	ALB	P02768	1/20	0.84

▸	CNR1	P21554	1/20	0.84

▸	HTR2A	P28223	1/20	0.84

▸	AOX1	Q06278	1/20	0.84

▸	CYP1B1	Q16678	1/20	0.84

▸	ABCB11	O95342	2/20	0.81

▸	ABCC4	O15439	1/20	0.81

▸	SLCO1B3	Q9NPD5	3/20	0.78

▸	SLCO1B1	Q9Y6L6	3/20	0.78

▸	MAPK1	P28482	2/20	0.78

▸	AR	P10275	1/20	0.78

▸	PGR	P06401	1/20	0.73

▸	HTR1A	P08908	1/20	0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Erythromycin SCHEMBL10899617	1.00	CYP3A4 (0.84)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL536998	0.99	CYP3A4 (0.86)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL29116300	0.99	CYP3A4 (0.86)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL40641	0.99	CYP3A4 (0.86)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL11340606	0.99	CYP3A4 (0.86)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL11340609	0.99	CYP3A4 (0.86)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL7056963	0.94	CYP3A4 (0.93)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL7056958	0.94	CYP3A4 (0.93)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL10900217	0.94	CYP3A4 (0.95)	CYP3A4KCNH2ABCB1TSHRLMNA
Erythromycin SCHEMBL9054352	0.94	CYP3A4 (0.95)	CYP3A4KCNH2ABCB1TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-117384259-A	Cell penetrating peptides based on influenza virus M2 proteins	中国医学科学院基础医学研究所	2024-01-12	—	—	CN	claimed
CN-112912386-B	Cell penetrating peptides based on influenza virus M2 proteins	中国医学科学院基础医学研究所	2023-10-20	—	—	CN	claimed
CN-117384259-A	Cell penetrating peptides based on influenza virus M2 proteins	中国医学科学院基础医学研究所	2024-01-12	—	—	CN	disclosed
CN-112912386-B	Cell penetrating peptides based on influenza virus M2 proteins	中国医学科学院基础医学研究所	2023-10-20	—	—	CN	disclosed
CN-116212048-A	Cell surface coupling of nanoparticles	麻省理工学院	2023-06-06	—	—	CN	disclosed
CN-114599386-A	Compositions and synergistic methods for treating infections	生物保护医疗公司	2022-06-07	—	—	CN	disclosed
CN-108786619-B	Bone material dispensing apparatus and method	华沙整形外科股份有限公司	2022-03-04	—	—	CN	disclosed
CN-109561990-B	Tympanogram patch applicator	泰姆克瑞有限公司	2021-10-15	—	—	CN	disclosed
CN-106852146-B	Cell penetrating peptides and methods of making and using the same	恩特拉达治疗学股份有限公司	2021-08-13	—	—	CN	disclosed
US-4599326-A	ANTIBIOTIC, GOOD ABSORBABILITY/	ORION-YHTYMA OY (FI)	1986-07-08	—	—	US	disclosed