Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | HPSE | Q9Y251 | 8/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | CHAT | P28329 | 1/20 | 0.40 |
| ▸ | TIMP3 | P35625 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.39 |
| ▸ | ENTPD3 | O75355 | 1/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | CBX7 | O95931 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10902168 | 0.83 | TTR (0.53) | TTRCYP1A2MEN1KMT2AMAPT | |
| SCHEMBL11765219 | 0.83 | TIMP3 (0.62) | HPSECYP1A2TIMP3MEN1USP2 | |
| SCHEMBL13899116 | 0.83 | TTR (0.49) | TTRHPSECYP1A2SNCACHAT | |
| SCHEMBL11798039 | 0.81 | TTR (0.46) | TTRHPSECYP1A2TIMP3MEN1 | |
| SCHEMBL6120265 | 0.80 | CD40 (0.50) | TTRCYP1A2TIMP3MEN1USP2 | |
| SCHEMBL2774792 | 0.79 | TTR (0.60) | TTRCYP1A2SNCACHATMEN1 | |
| SCHEMBL27480237 | 0.79 | SNCA (0.62) | TTRCYP1A2SNCACHATMEN1 | |
| SCHEMBL11761572 | 0.78 | HSD17B10 (0.51) | TTRHPSECYP1A2TIMP3MEN1 | |
| SCHEMBL2686041 | 0.77 | TTR (0.53) | TTRCYP1A2SNCACHATMEN1 | |
| SCHEMBL30233642 | 0.75 | TTR (0.75) | TTRCYP1A2SNCACHATMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4599203-A | Multisulfonated naphthalene ureas useful as complement inhibitors | AMERICAN CYANAMID COMPANY (US) | 1986-07-08 | — | — | US | disclosed |
| US-4591604-A | Method of inhibiting the complement system by administering multisulfonated naphthalene ureas | AMERICAN CYANAMID COMPANY (US) | 1986-05-27 | — | — | US | disclosed |