Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2RL3 | Q96RI0 | 4/20 | 0.41 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.35 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | SHBG | P04278 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL10899799 | 0.88 | MAOB (0.42) | MAOBESR1ESR2SHBG | |
| Iodide SCHEMBL10902259 | 0.79 | NPC1 (0.50) | MAOBESR1ESR2 | |
| Iodide SCHEMBL10901815 | 0.79 | SHBG (0.42) | F2RL3SHBG | |
| SCHEMBL10902110 | 0.79 | HIF1A (0.49) | F2RL3MAOBCSNK2A2CSNK2BCSNK2A1 | |
| Iodide SCHEMBL10900572 | 0.77 | MAOB (0.49) | F2RL3MAOBCSNK2A2CSNK2BCSNK2A1 | |
| Iodide SCHEMBL10902249 | 0.77 | MAOB (0.66) | MAOBESR1ESR2 | |
| Iodide SCHEMBL10902480 | 0.76 | ALDH1A1 (0.44) | ESR1ESR2 | |
| Iodide SCHEMBL10901680 | 0.73 | HIF1A (0.37) | MAOBESR1ESR2SHBGHIF1A | |
| Iodide SCHEMBL10898360 | 0.73 | MAOB (0.44) | MAOBESR1ESR2 | |
| Iodide SCHEMBL10901741 | 0.73 | MAOB (0.56) | MAOBESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4600719-A | Tetrahydropyridine and piperidine derivatives | CIBA GEIGY CORPORATION (US) | 1986-07-15 | — | — | US | disclosed |
| US-4210655-A | Anti-depressant benzofuranyl piperidines | CIBA-GEIGY CORPORATION (US) | 1980-07-01 | — | — | US | disclosed |