SCHEMBL10902136

SCHEMBL10902136

CCCCCCCCCCOC(=O)C1=C(C)NC(C)=C(C(=O)OCC)C1c1ccccc1OC(F)(F)F

nearest known ligand 0.66

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.54
CACNA1F O60840 6/20 0.52
CACNA1D Q01668 6/20 0.52
CACNA1S Q13698 6/20 0.52
CACNA1C Q13936 6/20 0.52
ALDH1A1 P00352 1/20 0.46
HTT P42858 1/20 0.46
NR1I2 O75469 1/20 0.46
PGR P06401 1/20 0.46
CYP3A4 P08684 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
CYP2C9 P11712 1/20 0.46
SLC6A2 P23975 1/20 0.46
TBXAS1 P24557 1/20 0.46
CYP2C19 P33261 1/20 0.46
DRD3 P35462 1/20 0.46
OPRK1 P41145 1/20 0.46
PDE4D Q08499 1/20 0.46
KCNH2 Q12809 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9876125 0.88 CACNA1C (0.54) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9875212 0.88 CACNA1C (0.54) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL9875740 0.88 CACNA1C (0.54) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10902324 0.87 LMNA (0.58) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10901014 0.85 CACNA1C (0.60) CACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10895484 0.85 NR1I2 (0.53) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10924809 0.84 LMNA (0.43) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10899707 0.82 LMNA (0.60) LMNACACNA1FCACNA1DCACNA1SCACNA1C
SCHEMBL10900760 0.80 CACNA1C (0.70) CACNA1FCACNA1DCACNA1SCACNA1CALDH1A1
SCHEMBL10896798 0.79 LMNA (0.61) LMNACACNA1FCACNA1DCACNA1SCACNA1C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4622332-A Asymmetric diesters of Hantzsch dihydropyridines with hypotensive activity BAYER AKTIENGESELLSCHAFT (DE) 1986-11-11 US disclosed