SCHEMBL10906375

SCHEMBL10906375

COC(=O)Cc1cc(Cc2ccccc2)c(O)c(Cc2ccccc2)c1

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HSP90AB1 P08238 1/20 0.53
PTPN1 P18031 3/20 0.53
PTPN2 P17706 1/20 0.53
PTPN6 P29350 1/20 0.53
ALOX5 P09917 1/20 0.48
BCL2 P10415 2/20 0.47
SLC7A5 Q01650 1/20 0.47
ALDH1A1 P00352 2/20 0.45
GAA P10253 1/20 0.45
GFER P55789 1/20 0.45
BCL2L1 Q07817 1/20 0.44
KDM4E B2RXH2 1/20 0.44
LMNA P02545 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25346475 0.91 PTPN1 (0.57) HSP90AB1PTPN1PTPN2PTPN6BCL2
SCHEMBL10907295 0.85 PTPN1 (0.50) PTPN1PTPN2PTPN6ALOX5ALDH1A1
SCHEMBL28169190 0.84 KDM4E (0.44) SLC7A5ALDH1A1KDM4ELMNA
SCHEMBL25348030 0.83 CNR2 (0.48) PTPN1PTPN2PTPN6ALDH1A1
SCHEMBL30792641 0.83 CNR2 (0.48) PTPN1PTPN2PTPN6ALDH1A1
SCHEMBL10903344 0.82 ALOX5 (0.52) PTPN1PTPN2PTPN6ALOX5BCL2
SCHEMBL10906416 0.82 PTPN1 (0.60) PTPN1PTPN2PTPN6BCL2BCL2L1
SCHEMBL10906219 0.81 PTPN1 (0.49) PTPN1PTPN2PTPN6ALOX5BCL2
SCHEMBL24051897 0.80 MTNR1A (0.49) SLC7A5ALDH1A1KDM4ELMNA
SCHEMBL6239887 0.80 CYP4F2 (0.59) SLC7A5ALDH1A1KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4613642-A ANTIOXIDANTS FOR POLYOLEFINS ETHYL CORPORATION (US) 1986-09-23 US disclosed