SCHEMBL10907307

SCHEMBL10907307

C/C(=C\C#N)CN1C(=O)c2cc(C(F)(F)F)ccc2S1(O)O

nearest known ligand 0.33

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
CA12 O43570 2/20 0.33
CA9 Q16790 2/20 0.33
CA1 P00915 1/20 0.33
NOTUM Q6P988 1/20 0.32
ATM Q13315 1/20 0.32
ALDH1A1 P00352 3/20 0.31
ALDH3A1 P30838 3/20 0.31
ALDH2 P05091 2/20 0.31
PTGDR2 Q9Y5Y4 5/20 0.31
PPARD Q03181 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10907309 1.00 CA12 (0.33) CA12CA9CA1NOTUMATM
SCHEMBL10884432 0.89 CA12 (0.42) CA12CA9CA1ATM
SCHEMBL10908992 0.85 CA12 (0.32) CA12CA9CA1
SCHEMBL10881532 0.85 CA12 (0.32) CA12CA9CA1
SCHEMBL10907321 0.83 GABRA1 (0.37) CA12CA9CA1
SCHEMBL10883413 0.83 GABRA1 (0.37) CA12CA9CA1
SCHEMBL10907274 0.80 CNR1 (0.34)
SCHEMBL10882230 0.80 CA9 (0.47) CA12CA9ALDH1A1
SCHEMBL10882241 0.80 CA9 (0.47) CA12CA9ALDH1A1
SCHEMBL10908170 0.76 HTR2C (0.34) CA12CA9CA1NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4563474-A PSYCHOLOGICAL DISORDERS BASF AKTIENGESELLSCHAFT (DE) 1986-01-07 US disclosed