SCHEMBL10908992

SCHEMBL10908992

C/C(=C\C#N)CN1C(=O)c2cc(F)ccc2S1(O)O

nearest known ligand 0.32

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CA12 O43570 3/20 0.32
CA9 Q16790 3/20 0.32
NPC1 O15118 1/20 0.32
CA1 P00915 1/20 0.32
RAB9A P51151 1/20 0.32
PARK7 Q99497 1/20 0.32
CA2 P00918 2/20 0.30
TRPA1 O75762 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10881532 1.00 CA12 (0.32) CA12CA9NPC1CA1RAB9A
SCHEMBL10881528 0.88 CA12 (0.44) CA12CA9NPC1CA1RAB9A
SCHEMBL10881530 0.88 CA12 (0.44) CA12CA9NPC1CA1RAB9A
SCHEMBL10883413 0.86 GABRA1 (0.37) CA12CA9CA1CA2
SCHEMBL10907321 0.86 GABRA1 (0.37) CA12CA9CA1CA2
SCHEMBL10907307 0.85 CA12 (0.33) CA12CA9CA1
SCHEMBL10907309 0.85 CA12 (0.33) CA12CA9CA1
SCHEMBL10907274 0.83 CNR1 (0.34)
SCHEMBL10882241 0.83 CA9 (0.47) CA12CA9NPC1RAB9ACA2
SCHEMBL10882230 0.83 CA9 (0.47) CA12CA9NPC1RAB9ACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4563474-A PSYCHOLOGICAL DISORDERS BASF AKTIENGESELLSCHAFT (DE) 1986-01-07 US disclosed