Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 14/20 | 0.61 |
| ▸ | PDE4A | P27815 | 8/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.48 |
| ▸ | CBFB | Q13951 | 1/20 | 0.48 |
| ▸ | PDE2A | O00408 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | METAP1 | P53582 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9634875 | 0.91 | PDE5A (0.57) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635949 | 0.85 | PDE5A (0.64) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9636334 | 0.85 | PDE5A (0.67) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9634857 | 0.83 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635725 | 0.83 | PDE5A (0.55) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635710 | 0.82 | PDE5A (0.56) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635759 | 0.81 | PDE5A (0.70) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635743 | 0.80 | PDE2A (0.60) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9635778 | 0.80 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL9634842 | 0.80 | PDE5A (0.63) | PDE5APDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |