Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TERT | O14746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10909950 | 0.97 | TERT (0.45) | POLBTERTALDH1A1KMT2AMEN1 | |
| SCHEMBL10913826 | 0.91 | TERT (0.47) | POLBTERTALDH1A1KMT2AMEN1 | |
| SCHEMBL10909601 | 0.91 | CHRNB2 (0.46) | POLBTERTALDH1A1KMT2AMEN1 | |
| SCHEMBL10913849 | 0.90 | TERT (0.46) | POLBTERTALDH1A1KMT2AMEN1 | |
| Nitric Acid SCHEMBL10911785 | 0.90 | MAPT (0.46) | POLBKMT2AKDM4E | |
| SCHEMBL10912048 | 0.87 | POLB (0.46) | POLBTERTALDH1A1KMT2AMEN1 | |
| SCHEMBL10911656 | 0.86 | POLB (0.45) | POLBTERTALDH1A1KMT2AMEN1 | |
| SCHEMBL10909554 | 0.86 | MAPT (0.48) | POLBKMT2AKDM4E | |
| SCHEMBL10912064 | 0.84 | PDK2 (0.45) | POLBALDH1A1KMT2AMEN1KDM4E | |
| Nitric Acid SCHEMBL10909522 | 0.84 | POLB (0.43) | POLBALDH1A1KMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0171977-A1 | Phthalimide derivatives, compositions containing them and a process for preparing them | SANKYO COMPANY LIMITED (JP) | 1986-02-19 | — | — | EP | disclosed |