Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681255 | 0.89 | PTGS2 (0.51) | PTGS2ABCB11CXCL8AKR1B1PTGS1 | |
| SCHEMBL7675435 | 0.87 | PTGS2 (0.57) | PTGS2ABCB11CXCL8AKR1B1PTGS1 | |
| SCHEMBL10923503 | 0.87 | KMT2A (0.46) | PTGS2ABCB11MEN1KMT2AKDM4E | |
| SCHEMBL10920459 | 0.82 | KMT2A (0.44) | MEN1KMT2AKDM4EHTTALDH1A1 | |
| SCHEMBL11768008 | 0.79 | PTGS2 (0.49) | PTGS2ABCB11CXCL8AKR1B1PTGS1 | |
| SCHEMBL10920481 | 0.77 | TSHR (0.47) | MEN1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11189853 | 0.76 | PTGS2 (0.46) | PTGS2ABCB11CXCL8AKR1B1PTGS1 | |
| SCHEMBL7682518 | 0.76 | HPGD (0.41) | PTGS2CXCL8AKR1B1PTGS1GLO1 | |
| SCHEMBL11713537 | 0.75 | PTGS2 (0.53) | PTGS2ABCB11CXCL8AKR1B1PTGS1 | |
| SCHEMBL11084405 | 0.75 | SMN1; SMN2 (0.36) | PTGS2CXCL8AKR1B1PTGS1GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0067370-B1 | PROCESS FOR THE PREPARATION OF ZOMEPIRAC AND RELATED COMPOUNDS | MERCK & CO. INC. (US) | 1986-03-19 | — | — | EP | disclosed |
| US-4374997-A | Process for the preparation of zomepirac and related compounds | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| EP-0067370-A2 | Process for the preparation of zomepirac and related compounds | MERCK & CO. INC. (US) | 1982-12-22 | — | — | EP | disclosed |