Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 18/20 | 0.58 |
| ▸ | CA1 | P00915 | 5/20 | 0.49 |
| ▸ | CA4 | P22748 | 3/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.49 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.49 |
| ▸ | CA7 | P43166 | 1/20 | 0.49 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14299650 | 0.85 | CA2 (0.61) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10913249 | 0.84 | CA2 (0.54) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10914045 | 0.82 | CA2 (0.56) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10915438 | 0.79 | CA2 (0.52) | CA2CA1CA4CA12CA14 | |
| SCHEMBL10914588 | 0.78 | CA2 (0.51) | CA2CA1CA4CA12CA14 | |
| SCHEMBL6785212 | 0.75 | AKR1C3 (0.48) | AKR1C3AKR1C2 | |
| SCHEMBL10939891 | 0.75 | KDM4E (0.58) | AKR1C3AKR1C2 | |
| SCHEMBL7924827 | 0.74 | CA2 (0.82) | CA2CA1 | |
| SCHEMBL14317794 | 0.74 | CA2 (0.67) | CA2CA1CA4CA12CA14 | |
| SCHEMBL564235 | 0.74 | CA2 (1.00) | CA2CA1CA4CA12CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091367-B1 | BENZOTHIAZOLESULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1986-06-18 | — | — | EP | claimed |