Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 17/20 | 0.54 |
| ▸ | CA1 | P00915 | 7/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA4 | P22748 | 3/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.46 |
| ▸ | CA7 | P43166 | 2/20 | 0.46 |
| ▸ | CA6 | P23280 | 2/20 | 0.45 |
| ▸ | CA5A | P35218 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CA3 | P07451 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913232 | 0.84 | CA2 (0.58) | CA2CA1CA12CA4CA14 | |
| SCHEMBL10914045 | 0.79 | CA2 (0.56) | CA2CA1CA12CA4CA14 | |
| SCHEMBL14299650 | 0.79 | CA2 (0.61) | CA2CA1CA12CA4CA14 | |
| SCHEMBL10915438 | 0.76 | CA2 (0.52) | CA2CA1CA12CA4CA14 | |
| SCHEMBL10914588 | 0.75 | CA2 (0.51) | CA2CA1CA12CA4CA14 | |
| SCHEMBL10913446 | 0.73 | CA2 (0.61) | CA2CA1CA12CA4CA14 | |
| SCHEMBL143678 | 0.72 | RAB9A (0.58) | KDM4ELMNAPKMKMT2AAKR1C3 | |
| SCHEMBL7924807 | 0.72 | CA2 (0.82) | CA2CA1 | |
| SCHEMBL564235 | 0.71 | CA2 (1.00) | CA2CA1CA12CA4CA14 | |
| SCHEMBL14317794 | 0.71 | CA2 (0.67) | CA2CA1CA12CA4CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0091367-B1 | BENZOTHIAZOLESULFONAMIDE DERIVATIVES FOR THE TOPICAL TREATMENT OF ELEVATED INTRAOCULAR PRESSURE | MERCK & CO. INC. (US) | 1986-06-18 | — | — | EP | claimed |
| US-4426388-A | 5-Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO., INC. (US) | 1984-01-17 | — | — | US | disclosed |
| EP-0091367-A2 | Benzothiazolesulfonamide derivatives for the topical treatment of elevated intraocular pressure | MERCK & CO. INC. (US) | 1983-10-12 | — | — | EP | disclosed |