Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 2/20 | 0.43 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.43 |
| ▸ | MMP1 | P03956 | 6/20 | 0.39 |
| ▸ | MMP3 | P08254 | 6/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913716 | 1.00 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10913722 | 1.00 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10895110 | 1.00 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10691419 | 0.99 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| Pidolic Acid SCHEMBL10914420 | 0.86 | PLA2G10 (0.39) | PLA2G10PLA2G5MMP1MMP3F2 | |
| Pidolic Acid SCHEMBL10914329 | 0.86 | PLA2G10 (0.39) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10896372 | 0.84 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10911583 | 0.84 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL10914619 | 0.84 | PLA2G10 (0.43) | PLA2G10PLA2G5MMP1MMP3F2 | |
| SCHEMBL12495091 | 0.83 | MMP1 (0.52) | MMP1MMP3F2ACEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4587050-A | Substituted enantholactam derivatives as antihypertensives | MERCK & CO., INC. (US) | 1986-05-06 | — | — | US | disclosed |
| EP-0046289-A2 | Substituted enantholactam derivatives as antihypertensives, a process for preparing and a pharmaceutical composition containing them, and intermediates | MERCK & CO. INC. (US) | 1982-02-24 | — | — | EP | disclosed |