SCHEMBL1092

SCHEMBL1092

CCCc1cc(C(=O)O)[nH]n1

nearest known ligand 0.54

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HCAR3 P49019 8/20 0.54
HCAR2 Q8TDS4 6/20 0.50
ALPL P05186 5/20 0.47
CA9 Q16790 2/20 0.47
CA12 O43570 2/20 0.47
TP53 P04637 1/20 0.43
KDM4E B2RXH2 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL31467460 0.98 HCAR3 (0.53) HCAR3HCAR2ALPLCA9CA12
SCHEMBL1527555 0.89 HCAR2 (0.53) HCAR3HCAR2ALPLCA9CA12
SCHEMBL16763221 0.88 HCAR3 (0.50) HCAR3HCAR2ALPLCA9CA12
Hydrochloric Acid SCHEMBL27449787 0.88 HCAR2 (0.51) HCAR3HCAR2ALPLCA9CA12
SCHEMBL4790447 0.88 HCAR2 (0.54) HCAR3HCAR2ALPLCA9CA12
SCHEMBL1431995 0.85 ALPL (0.54) HCAR3HCAR2ALPLCA9CA12
SCHEMBL6622541 0.84 PLA2G10 (0.42) HCAR3HCAR2ALPLCA9CA12
SCHEMBL5599241 0.82 HCAR3 (0.47) HCAR3HCAR2ALPLCA9CA12
SCHEMBL6109395 0.82 HCAR3 (0.43) HCAR3HCAR2ALPLCA9CA12
SCHEMBL6109448 0.81 HCAR3 (0.45) HCAR3HCAR2ALPLCA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109721538-A A kind of novel synthesis of 1- methyl -3- propylpyrazol -5- carboxylic acid 孙双 2019-05-07 CN claimed
EP-1362049-A1 NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES L'OREAL (FR) 2003-11-19 EP claimed
WO-2002064596-A1 NOVEL PYRAZOLO-TRIAZOLES AND USE OF SAID COMPOUNDS FOR DYEING KERATINOUS FIBRES L'OREAL (FR) 2002-08-22 WO claimed
EP-1077214-A1 An improved process for preparing a pyrazolopyrimidinone derivative Orchid Chemicals & Pharmaceuticals Ltd. (IN) 2001-02-21 EP claimed
EP-3157938-B1 HETERO FUNCTIONAL BINDING SYSTEMS ANTEO TECH PTY LTD (AU) 2022-03-16 EP disclosed
US-10768176-B2 Hetero functional binding systems ANTEO TECHNOLOGIES PTY LTD (AU) 2020-09-08 US disclosed
US-20170115285-A1 HETERO FUNCTIONAL BINDING SYSTEMS ANTEO TECHNOLOGIES PTY LTD (AU) 2017-04-27 US disclosed
EP-3157938-A1 HETERO FUNCTIONAL BINDING SYSTEMS Anteo Technologies Pty Ltd. (AU) 2017-04-26 EP disclosed
WO-2016120530-A1 A CARBOXAMIDE DERIVATIVE AND ITS DIASTEREOMERS IN STABLE CRYSTALLINE FORM ORION CORPORATION (FI) 2016-08-04 WO disclosed
WO-2015192183-A1 HETERO FUNCTIONAL BINDING SYSTEMS ANTEO TECHNOLOGIES PTY LTD (AU) 2015-12-23 WO disclosed
EP-2261210-B1 3-SUBSTITUTED SULFONYL PIPERAZINE DERIVATIVE MSD KK (JP) 2014-10-22 EP disclosed
US-8367698-B2 3-substituted sulfonyl piperidine derivative MSD K.K. (JP) 2013-02-05 US disclosed
CN-1034503-C Pyrazolopyrimidinone antianginal agents PFIZER (US) 1997-04-09 CN disclosed
CN-1028758-C Pyrazolopyrimidinone antianginal agents PFIZER (US) 1995-06-07 CN disclosed
EP-0463756-B1 Pyrazolopyrimidinone antianginal agents PFIZER LTD (GB) 1995-04-19 EP disclosed
US-5346901-A Treatment of angina, hypertension, heart failure and atherosclerosis PFIZER INC. (US) 1994-09-13 US disclosed
US-5250534-A Inhibitors of cyclic guanosine 3*,5*-monophosphate phosphodiesterase PFIZER INC. (US) 1993-10-05 US disclosed
CN-1068329-A Pyrazolopyrimidinoneantianginal antianginal agents PFIZER (US) 1993-01-27 CN disclosed
EP-0463756-A1 Pyrazolopyrimidinone antianginal agents Pfizer Limited (GB) 1992-01-02 EP disclosed
CN-1057464-A Pyrazolopyrimidinoneantianginal antianginal agents PFIZER (US) 1992-01-01 CN disclosed