Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Phosphoric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 6/20 | 0.86 |
| ▸ | ATP4B | P51164 | 6/20 | 0.86 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | BLM | P54132 | 1/20 | 0.58 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2191144 | 0.93 | ATP4A (1.00) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2195617 | 0.83 | ATP4A (0.81) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2189454 | 0.82 | ATP4A (0.79) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15609152 | 0.80 | ATP4A (0.68) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2193469 | 0.80 | ATP4A (0.76) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11064908 | 0.80 | ATP4A (0.68) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8816284 | 0.79 | ATP4A (0.74) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11064126 | 0.78 | ATP4A (0.73) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14231824 | 0.78 | ATP4A (0.65) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL1813915 | 0.78 | ATP4A (1.00) | ATP4AATP4BCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068378-B1 | NOVEL IMIDAZO(1,2-A)PYRIDINES AND PYRAZINES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1986-03-05 | — | — | EP | disclosed |
| US-4450164-A | ANTIULCER AND ANTISECRETORY AGENTS | SCHERING CORPORATION (US) | 1984-05-22 | — | — | US | disclosed |
| EP-0068378-A1 | Novel imidazo(1,2-a)pyridines and pyrazines, processes for their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1983-01-05 | — | — | EP | disclosed |