Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 4/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | BRD2 | P25440 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA3 | P07451 | 1/20 | 0.34 |
| ▸ | CA4 | P22748 | 1/20 | 0.34 |
| ▸ | CA6 | P23280 | 1/20 | 0.34 |
| ▸ | CA5A | P35218 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL909148 | 0.94 | KMT2A (0.37) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL3350811 | 0.92 | KMT2A (0.40) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL9034448 | 0.86 | — | — | |
| SCHEMBL6849692 | 0.83 | TSHR (0.47) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL5476941 | 0.81 | BRD4 (0.41) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL11884023 | 0.79 | BRD4 (0.40) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL6348530 | 0.76 | LMNA (0.36) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL19318547 | 0.76 | BRD4 (0.38) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL11752882 | 0.76 | LMNA (0.40) | LMNAALDH1A1TSHRBRD4BRD2 | |
| SCHEMBL19323033 | 0.76 | LMNA (0.41) | LMNAALDH1A1TSHRBRD4BRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101454313-A | P38 inhibitors and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2009-06-10 | — | — | CN | disclosed |
| EP-0071216-B1 | 3-HYDROXYPYRROLIDIN-2-ONE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1986-12-30 | — | — | EP | disclosed |
| US-4416684-A | PYRROLIDONE AND M-UREIDOPHENYL CARBAMATE | STAUFFER CHEMICAL COMPANY (US) | 1983-11-22 | — | — | US | disclosed |