Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HTR2B | P41595 | 1/20 | 0.49 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.47 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 2/20 | 0.47 |
| ▸ | PDE7B | Q9NP56 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.40 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10922543 | 0.88 | IDO1 (0.50) | HTR2AHTR2CHTR2BPDE7AMAPT | |
| SCHEMBL11155968 | 0.83 | HTR2A (0.54) | HTR2AHTR2CHTR2BGSTP1GSTM2 | |
| SCHEMBL10702801 | 0.80 | PDE7A (0.51) | HTR2AHTR2CHTR2BGSTP1GSTM2 | |
| SCHEMBL10922857 | 0.80 | PDE7A (0.45) | HTR2AHTR2CHTR2BPDE7APDE7B | |
| Hydrochloric Acid SCHEMBL10702259 | 0.79 | PDE7A (0.50) | HTR2AHTR2CHTR2BGSTP1GSTM2 | |
| SCHEMBL10923605 | 0.76 | CHRNA7 (0.44) | MAPTSMN1; SMN2TDP1ALDH1A1HPGD | |
| SCHEMBL10925142 | 0.76 | ADRA2A (0.49) | SMN1; SMN2NPSR1CHRNA7 | |
| SCHEMBL11219447 | 0.76 | CHRNA7 (0.44) | SMN1; SMN2TDP1ALDH1A1CHRNA7 | |
| Hydrochloric Acid SCHEMBL10917968 | 0.75 | CHRNA7 (0.43) | MAPTSMN1; SMN2TDP1ALDH1A1HPGD | |
| SCHEMBL11038468 | 0.73 | ADRA2A (0.51) | MEN1KMT2ASMN1; SMN2TDP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-B1 | 6-CHLORO-3-METHYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE, ITS ACID ADDITION SALTS AND ITS USE AS AN INTERMEDIATE | SMITHKLINE BECKMAN CORPORATION (US) | 1986-04-09 | — | — | EP | disclosed |
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |