Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | DRD1 | P21728 | 5/20 | 0.44 |
| ▸ | DRD5 | P21918 | 4/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPY1R | P25929 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.41 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923605 | 0.82 | CHRNA7 (0.44) | CHRNA7DRD2DRD1DRD5DRD3 | |
| SCHEMBL10925142 | 0.82 | ADRA2A (0.49) | CHRNA7DRD2DRD1DRD5DRD4 | |
| Hydrochloric Acid SCHEMBL10917968 | 0.81 | CHRNA7 (0.43) | CHRNA7DRD2DRD1DRD5DRD3 | |
| SCHEMBL11162576 | 0.80 | DRD1 (0.48) | CHRNA7DRD2DRD1DRD5DRD3 | |
| SCHEMBL11038468 | 0.78 | ADRA2A (0.51) | CHRNA7DRD2DRD1DRD5DRD3 | |
| SCHEMBL10700283 | 0.78 | DRD1 (0.49) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL10701215 | 0.77 | DRD1 (0.53) | CHRNA7DRD2DRD1DRD5DRD3 | |
| SCHEMBL11160077 | 0.77 | DRD1 (0.46) | CHRNA7DRD2DRD1DRD5DRD3 | |
| Hydrochloric Acid SCHEMBL10703949 | 0.77 | DRD1 (0.48) | DRD2DRD1DRD5DRD3DRD4 | |
| SCHEMBL10920864 | 0.76 | HTR2A (0.49) | CHRNA7SMN1; SMN2ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |