Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 7/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1334863 | 0.77 | HTR2A (0.44) | OPRM1SLC6A2SLC6A4SLC6A3HTR2A | |
| Bromide SCHEMBL5224748 | 0.76 | HTR2A (0.43) | OPRM1SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL5385849 | 0.75 | HDAC4 (0.37) | OPRM1SLC6A2SLC6A4SLC6A3HTR2A | |
| SCHEMBL26633128 | 0.74 | SLC6A2 (0.33) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10785548 | 0.74 | OPRM1 (0.51) | OPRM1SLC6A2SLC6A4SLC6A3CHRNB2 | |
| SCHEMBL8934433 | 0.74 | NPC1 (0.38) | SLC6A2SLC6A4HTR2AHTR2CDRD2 | |
| SCHEMBL30717248 | 0.74 | TSHR (0.39) | OPRM1SLC6A2SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL1332923 | 0.72 | SLC6A2 (0.41) | OPRM1SLC6A2SLC6A4SLC6A3CHRNB2 | |
| SCHEMBL28326295 | 0.72 | CHRNB2 (0.31) | SLC6A2SLC6A4SLC6A3CHRNB2CHRNB4 | |
| SCHEMBL26633114 | 0.71 | PDK2 (0.39) | SLC6A2SLC6A4SLC6A3HTR2CCHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080940-B1 | DERIVATIVES OF 2-PHENYL-MORPHOLINE AND MEDICAL COMPOSITIONS | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1986-02-19 | — | — | EP | disclosed |
| EP-0080940-A2 | Derivatives of 2-phenyl-morpholine and medical compositions | LABORATOIRE L. LAFON Société anonyme dite: (FR) | 1983-06-08 | — | — | EP | disclosed |