Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 4/20 | 0.40 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.37 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.37 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.37 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.37 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923467 | 0.92 | ALDH1A1 (0.44) | AKR1C3AKR1C2ALDH1A1PKMMAPT | |
| SCHEMBL10915306 | 0.89 | MAPT (0.46) | ALDH1A1PKMMAPTMEN1KMT2A | |
| SCHEMBL10911007 | 0.89 | ALDH1A1 (0.46) | AKR1C3AKR1C2ALDH1A1PKMMAPT | |
| SCHEMBL10913546 | 0.87 | MEN1 (0.42) | AKR1C3AKR1C2ALDH1A1PKMMAPT | |
| SCHEMBL10913336 | 0.85 | PDE1C (0.45) | AKR1C3AKR1C2ALDH1A1PKMMAPT | |
| SCHEMBL10913778 | 0.85 | CACNA1F (0.47) | ALDH1A1PKMMAPTMEN1KMT2A | |
| SCHEMBL10914210 | 0.85 | ALDH1A1 (0.44) | ALDH1A1PKMMAPTMEN1KMT2A | |
| SCHEMBL10920218 | 0.84 | ALDH1A1 (0.41) | AKR1C3AKR1C2ALDH1A1PKMMAPT | |
| SCHEMBL10748135 | 0.84 | ACHE (0.48) | ALDH1A1PKMMAPTMEN1KMT2A | |
| SCHEMBL10924108 | 0.83 | ALDH1A1 (0.43) | AKR1C3AKR1C2ALDH1A1PKMMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |