Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.55 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 6/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923393 | 0.90 | ALDH1A1 (0.57) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL10919811 | 0.89 | MEN1 (0.57) | MEN1KMT2AGAAALDH1A1KDM4E | |
| Amifloxacin SCHEMBL29371634 | 0.88 | ALDH1A1 (0.70) | MEN1KMT2AGAAALDH1A1KDM4E | |
| Amifloxacin SCHEMBL28198749 | 0.88 | ALDH1A1 (0.70) | MEN1KMT2AGAAALDH1A1KDM4E | |
| Amifloxacin SCHEMBL48001 | 0.88 | ALDH1A1 (0.70) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL10942258 | 0.87 | ALDH1A1 (0.55) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| Amifloxacin SCHEMBL9788088 | 0.87 | ALDH1A1 (0.69) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL2859863 | 0.87 | ALDH1A1 (0.57) | MEN1KMT2AGAAALDH1A1KDM4E | |
| SCHEMBL9159906 | 0.87 | ALDH1A1 (0.70) | MEN1KMT2AALDH1A1KDM4EHPGD | |
| SCHEMBL10918825 | 0.86 | KDM4E (0.70) | MEN1KMT2AALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499091-A | 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents | STERLING DRUG INC. (US) | 1985-02-12 | — | — | US | claimed |
| EP-0090424-B1 | NEW QUINOLONE COMPOUNDS AND PREPARATION THEREOF | STERLING DRUG INC. (US) | 1986-05-28 | — | — | EP | disclosed |
| US-4499091-A | 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-heterylquinoline-3-carboxylic acids and their use as antibacterial agents | STERLING DRUG INC. (US) | 1985-02-12 | — | — | US | disclosed |