Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | DRD3 | P35462 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MEN1 | O00255 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.55 |
| ▸ | HPGD | P15428 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 1/20 | 0.53 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amifloxacin SCHEMBL28198749 | 0.90 | ALDH1A1 (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| Amifloxacin SCHEMBL48001 | 0.90 | ALDH1A1 (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| Amifloxacin SCHEMBL29371634 | 0.90 | ALDH1A1 (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL10923393 | 0.90 | ALDH1A1 (0.57) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| Amifloxacin SCHEMBL9788088 | 0.89 | ALDH1A1 (0.69) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL10919811 | 0.89 | MEN1 (0.57) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL10918825 | 0.88 | KDM4E (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL10918967 | 0.87 | ALDH1A1 (0.55) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL10923458 | 0.87 | KDM4E (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A | |
| SCHEMBL9159906 | 0.87 | ALDH1A1 (0.70) | ALDH1A1DRD3KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2010-10-28 | — | — | US | claimed |
| EP-2222662-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | University of Maryland, Baltimore (US) | 2010-09-01 | — | — | EP | claimed |
| WO-2009064836-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2009-05-22 | — | — | WO | claimed |
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2010-10-28 | — | — | US | disclosed |
| EP-2222662-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | University of Maryland, Baltimore (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009064836-A2 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2009-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100273787-A1 | KYNURENINE-AMINOTRANSFERASE INHIBITORS | KYNU, AADAT, KMO | ALDH1A1 616/4885DRD3 1261/4885KDM4E 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.