Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.38 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.38 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921719 | 0.96 | SMN1; SMN2 (0.46) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL6955861 | 0.91 | ALDH1A1 (0.49) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL10921995 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL6962713 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL6955568 | 0.77 | NPC1 (0.48) | SMN1; SMN2NPSR1MAPTKDM4ELMNA | |
| SCHEMBL10920420 | 0.76 | ALDH1A1 (0.46) | MAPTHPGDALDH1A1RAB9ACACNB4 | |
| SCHEMBL10924017 | 0.75 | AKR1C3 (0.45) | SMN1; SMN2MAPTHPGDALDH1A1RAB9A | |
| SCHEMBL11013037 | 0.75 | SMN1; SMN2 (0.63) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL10914513 | 0.75 | DPP4 (0.34) | SMN1; SMN2NPSR1MAPTKDM4EHPGD | |
| SCHEMBL11010179 | 0.74 | SMN1; SMN2 (0.66) | SMN1; SMN2NPSR1MAPTKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |