Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.35 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10914513 | 0.91 | DPP4 (0.34) | SMN1; SMN2MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL10921719 | 0.89 | SMN1; SMN2 (0.46) | SMN1; SMN2MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL10910998 | 0.88 | LMNA (0.37) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL10914187 | 0.88 | HPGD (0.41) | SMN1; SMN2MAPTLMNAALDH1A1KDM4E | |
| SCHEMBL10915172 | 0.86 | L3MBTL1 (0.38) | SMN1; SMN2LMNAALDH1A1KDM4ENPC1 | |
| SCHEMBL10913013 | 0.85 | SMN1; SMN2 (0.34) | SMN1; SMN2MAPTLMNAGAATSHR | |
| SCHEMBL10923799 | 0.85 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPTLMNAALDH1A1NPSR1 | |
| SCHEMBL10914228 | 0.85 | TDP1 (0.41) | SMN1; SMN2MAPTGAARAB9AMEN1 | |
| SCHEMBL10914725 | 0.85 | CPB1 (0.36) | SMN1; SMN2ALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL10913637 | 0.84 | PTPN11 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0088938-B1 | USE OF PYRIDINE COMPOUNDS FOR THE MANUFACTURE OF MEDICAMENTS WITH AN ANTIHYPOXEMIA AND ISCHEMIA-PROTECTIVE ACTIVITY | BAYER AG (DE) | 1986-04-30 | — | — | EP | disclosed |
| EP-0088940-A1 | Pyridine-carboxylic-acid esters, process for their preparation and their use as pharmaceutical compositions | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |
| EP-0088938-A1 | Use of pyridine compounds for the manufacture of medicaments with an antihypoxemia and ischemia-protective activity | BAYER AG (DE) | 1983-09-21 | — | — | EP | disclosed |