Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 3/20 | 0.42 |
| ▸ | CCR8 | P51685 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1669125 | 0.82 | LMNA (0.67) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL6903991 | 0.79 | LMNA (0.53) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL6481012 | 0.79 | LMNA (0.53) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL462223 | 0.78 | LMNA (0.56) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL1615610 | 0.77 | LMNA (0.54) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL2528246 | 0.77 | LMNA (0.54) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL2950262 | 0.77 | LMNA (0.54) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL7610124 | 0.75 | LMNA (0.61) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL3298981 | 0.74 | LMNA (0.51) | LMNACYP3A4MAPTKDM4EALDH1A1 | |
| SCHEMBL10923588 | 0.74 | LMNA (0.78) | LMNACYP3A4MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0064317-B1 | PYRROLO(2,3-D)CARBAZOLE DERIVATIVES, PREPARATION THEREOF AND THEIR THERAPEUTICAL USE | OMNICHEM Société anonyme (BE) | 1986-02-26 | — | — | EP | disclosed |
| US-4428880-A | Azepino[4,5-d]indole derivatives and preparation thereof | S.A. OMNICHEM (BE) | 1984-01-31 | — | — | US | disclosed |
| EP-0011057-B1 | PROCESS FOR THE PREPARATION OF VINCADIFFORMINE AND DERIVATIVES THEREOF, INTERMEDIATES OBTAINED DURING THIS PROCESS AND PROCESS FOR THEIR PREPARATION | OMNICHEM Société anonyme (BE) | 1983-02-09 | — | — | EP | disclosed |
| US-4362739-A | Pyrrolo(2,3-d)carbazole derivatives, compositions and use | S.A. OMNICHEM (BE) | 1982-12-07 | — | — | US | disclosed |
| EP-0064317-A2 | Pyrrolo(2,3-d)carbazole derivatives, preparation thereof and their therapeutical use | OMNICHEM Société anonyme (BE) | 1982-11-10 | — | — | EP | disclosed |
| EP-0011057-A1 | Process for the preparation of vincadifformine and derivatives thereof, intermediates obtained during this process and process for their preparation | OMNICHEM Société anonyme (BE) | 1980-05-14 | — | — | EP | disclosed |