Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 2/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10928252 | 0.92 | TP53 (0.50) | TP53GFERDRD4NPC1RAB9A | |
| SCHEMBL10925373 | 0.82 | MEN1 (0.55) | TP53DRD4DRD2ALDH1A1MAPT | |
| SCHEMBL10923780 | 0.78 | MEN1 (0.55) | TP53DRD4DRD2HTR2AMAPT | |
| SCHEMBL10922803 | 0.75 | MEN1 (0.57) | TP53DRD4DRD2ALDH1A1MAPT | |
| SCHEMBL10926835 | 0.75 | HRH1 (0.53) | TP53DRD4DRD2HTR2AALDH1A1 | |
| SCHEMBL10928806 | 0.75 | THRB (0.56) | TP53NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL10924892 | 0.75 | LMNA (0.51) | TP53NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL10927399 | 0.73 | TSHR (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL10926532 | 0.73 | SMN1; SMN2 (0.55) | TP53DRD4DRD2ALDH1A1MAPT | |
| Fumaric Acid SCHEMBL10927363 | 0.72 | THRB (0.51) | TP53NPC1RAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | claimed |
| EP-0189771-A3 | (ISOXAZOL-3-YL)ARYLMETHANONES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-10-08 | — | — | EP | disclosed |
| EP-0189771-A2 | (Isoxazol-3-yl)arylmethanones, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1986-08-06 | — | — | EP | disclosed |
| US-4562187-A | HYPOTENSIVE AGENTS, ANTIINFLAMMATORY, AGENTS, AND ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1985-12-31 | — | — | US | disclosed |