Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | TYR | P14679 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9643304 | 0.98 | MAPT (0.49) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL6545119 | 0.95 | TLR8 (0.47) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| Formic Acid SCHEMBL27795499 | 0.91 | MAPT (0.47) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL17329242 | 0.88 | GPR84 (0.51) | KDM4EALDH1A1GAAHPGD | |
| SCHEMBL11126792 | 0.87 | KDM4E (0.47) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL8760245 | 0.87 | TYR (0.47) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL15486078 | 0.87 | MAPT (0.48) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL11221690 | 0.87 | KDM4E (0.50) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL11138231 | 0.86 | KDM4E (0.51) | TLR8MAPTCYP3A4KDM4EALDH1A1 | |
| SCHEMBL9456470 | 0.86 | KDM4E (0.51) | TLR8MAPTCYP3A4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4594442-A | Halogen containing alkoxy substitution | HOFFMAN-LA ROCHE INC. (US) | 1986-06-10 | — | — | US | disclosed |
| US-4539419-A | TREATMENT OF ALLERGIES | HOFFMANN-LA ROCHE INC. (US) | 1985-09-03 | — | — | US | disclosed |