Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.50 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10941178 | 0.91 | EGFR (0.52) | ALDH1A1TSHRLMNAGAAMAPT | |
| SCHEMBL1149848 | 0.87 | ALDH1A1 (0.69) | ALDH1A1TSHRLMNAGAAMAPT | |
| SCHEMBL10936378 | 0.86 | TDP1 (0.58) | ALDH1A1LMNAGAAMAPTBAZ2B | |
| SCHEMBL10941698 | 0.85 | GPR17 (0.47) | ALDH1A1TSHRLMNAGAABAZ2B | |
| SCHEMBL10940646 | 0.84 | ALDH1A1 (0.55) | ALDH1A1LMNAGAAMAPTBAZ2B | |
| SCHEMBL10946156 | 0.84 | NPC1 (0.61) | ALDH1A1LMNAGAAMAPTBAZ2B | |
| SCHEMBL10940195 | 0.84 | KMT2A (0.52) | ALDH1A1LMNAGAAMAPTBAZ2B | |
| SCHEMBL10945693 | 0.84 | MAPK7 (0.50) | ALDH1A1LMNAGAAMAPTBAZ2B | |
| SCHEMBL10940346 | 0.83 | ALDH1A1 (0.48) | ALDH1A1TSHRLMNAGAAMAPT | |
| SCHEMBL10937651 | 0.82 | ALDH1A1 (0.62) | ALDH1A1LMNAGAABAZ2BBAZ2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |