Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK7 | Q13164 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.44 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30874536 | 0.89 | ALDH1A1 (0.58) | MAPK7MAPK14DOT1LPOLBGFER | |
| SCHEMBL29191008 | 0.89 | ALDH1A1 (0.58) | MAPK7MAPK14DOT1LPOLBGFER | |
| SCHEMBL10941698 | 0.84 | GPR17 (0.47) | POLBALDH1A1GAALMNABAZ2B | |
| SCHEMBL10946156 | 0.84 | NPC1 (0.61) | ALDH1A1GAALMNAHPGDBAZ2B | |
| SCHEMBL10936334 | 0.84 | ALDH1A1 (0.57) | MAPK7ALDH1A1GAALMNABAZ2B | |
| SCHEMBL10940195 | 0.83 | KMT2A (0.52) | POLBALDH1A1GAALMNABAZ2B | |
| SCHEMBL10941754 | 0.82 | ALOX15 (0.51) | MAPK7MAPK14DOT1LALDH1A1GAA | |
| SCHEMBL10939142 | 0.80 | ALOX15 (0.49) | POLBGFERALDH1A1GAAHPGD | |
| SCHEMBL642345 | 0.80 | RAB9A (0.59) | POLBGFERALDH1A1HPGDNPC1 | |
| SCHEMBL29406761 | 0.80 | RAB9A (0.59) | POLBGFERALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511575-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4511576-A | Antidiabetic pyrrolecarboxylic acids | PFIZER INC. (US) | 1985-04-16 | — | — | US | disclosed |
| US-4351843-A | LOWERING BLOOD GLUCOSE | PFIZER INC. (US) | 1982-09-28 | — | — | US | disclosed |
| US-4282242-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1981-08-04 | — | — | US | disclosed |