Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.56 |
| ▸ | MMP8 | P22894 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | PPID | Q08752 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.44 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10934625 | 0.91 | RIPK1 (0.54) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL10937862 | 0.88 | RIPK1 (0.64) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL5606082 | 0.80 | RIPK1 (0.58) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL5693586 | 0.80 | RIPK1 (0.58) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL19176844 | 0.80 | RIPK1 (0.76) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL4068358 | 0.79 | EPHX2 (0.48) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL4068361 | 0.79 | EPHX2 (0.48) | RIPK1MMP8CYP2C19EPHX2CYP3A4 | |
| SCHEMBL2044492 | 0.78 | HTT (0.49) | RIPK1MMP8CYP2C19OPRK1SMN1; SMN2 | |
| SCHEMBL10936025 | 0.78 | RIPK1 (0.63) | RIPK1MMP8CYP2C19L3MBTL1OPRK1 | |
| SCHEMBL7438658 | 0.78 | RIPK1 (0.68) | RIPK1MMP8CYP2C19EPHX2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4537781-A | Pharmaceutically useful malonamides | RESEARCH CORPORATION (US) | 1985-08-27 | — | — | US | disclosed |
| EP-0135189-A2 | Pharmaceutically useful malonamides | Research Corporation (US) | 1985-03-27 | — | — | EP | disclosed |