Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.53 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.53 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7524436 | 0.85 | FTO (0.56) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL1093995 | 0.81 | HPGD (0.56) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL24943859 | 0.80 | FTO (0.59) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL7526450 | 0.80 | ALDH1A1 (0.59) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL5766096 | 0.80 | FTO (0.59) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL1669688 | 0.79 | HPGD (0.59) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL385190 | 0.78 | HPGD (0.53) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL6547973 | 0.78 | FTO (0.54) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL5316391 | 0.77 | HPGD (0.51) | HPGDALDH1A1ALOX12CYP2C9ALOX15 | |
| SCHEMBL6247181 | 0.76 | FTO (0.63) | HPGDALDH1A1ALOX12CYP2C9ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140888-B1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | VERTEX PHARMA SAN DIEGO LLC (US) | 2003-05-14 | — | — | EP | claimed |
| US-8153828-B2 | Optical molecular sensors for cytochrome P450 activity | Life Technologies Corporation (US) | 2012-04-10 | — | — | US | disclosed |
| US-20100105095-A1 | Optical Molecular Sensors for Cytochrome P450 Activity | Life Technologies Corporation (US) | 2010-04-29 | — | — | US | disclosed |
| US-20080125586-A1 | Optical molecular sensors for cytochrome P450 activity | INVITROGEN CORPORATION (US) | 2008-05-29 | — | — | US | disclosed |
| US-20070072256-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | INVITROGEN CORPORATION | 2007-03-29 | — | — | US | disclosed |
| US-7132252-B2 | Comprises fluorophores selected from 7-hydroxycoumarin derivtives, resorufin, and a fluorescein; drug screening | INVITROGEN CORPORATION (US) | 2006-11-07 | — | — | US | disclosed |
| US-20030186349-A1 | Optical molecular sensors for cytochrome P450 activity | Life Technologies Corporation | 2003-10-02 | — | — | US | disclosed |
| EP-1140888-B1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | VERTEX PHARMA SAN DIEGO LLC (US) | 2003-05-14 | — | — | EP | disclosed |
| US-6514687-B1 | Screening a candidate compound for activity as a Cytochrome P450 enzyme substrate by contacting the compound, enzyme, and a reagent chromogen comprising the ether of a phenolic dye such as a coumarin, resofurin or fluorescein dye | VERTEX PHARMACEUTICALS (SAN DIEGO), LLC | 2003-02-04 | — | — | US | disclosed |
| WO-2002004562-A2 | FLUORESCEIN-BASED METAL SENSORS, AND METHODS OF MAKING AND USING THE SAME | MASSACHUSSETS INSTITUTE OF TECHNOLOGY (US) | 2002-01-17 | — | — | WO | disclosed |
| EP-1140888-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | Aurora Biosciences Corporation (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035900-A1 | OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY | AURORA BIOSCIENCES CORPORATION (US) | 2000-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105095-A1 | Optical Molecular Sensors for Cytochrome P450 Activity | CYP2J2, CYP1A2, CYP2B6 | HPGD 1218/4885ALDH1A1 766/4885ALOX12 53/4885 |
| US-20080125586-A1 | Optical molecular sensors for cytochrome P450 activity | CYP2J2, CYP1A2, CYP2B6 | HPGD 1218/4885ALDH1A1 766/4885ALOX12 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.